PUBLICATIONS
Featured Papers
Demystifying Functional Parameters for Irreversible Enzyme Inhibitors
David E. Heppner,* Blessing C. Ogboo, Daniel A. Urul, Earl W. May, Erik M. Schaefer, Andrew S. Murkin*, and Matthias Gehringer.
J Med Chem 2024, 67, 14693-14696.
Methylthio-D-ribose-1-Phosphate Isomerase Uses a Novel Mechanism for Aldose–Ketose Isomerization
Subashi Ubayawardhana and Andrew S. Murkin*
ChemRxiv 16 April 2024
Kinetic Characterization of Methylthio-D-ribose-1-phosphate Isomerase
Vamsee M. Veeramachineni, Subashi Ubayawardhana, and Andrew S. Murkin*
Methods in Enzymology 2023, 685, 279-318.
Vamsee M. Veeramachineni, Subashi Ubayawardhana, and Andrew S. Murkin*
Biochemistry 2022, 61, 1124-1135.
α-Ketol Rearrangements in Synthetic Organic and Biological Reactions
Scott Benz and Andrew S. Murkin*
Beilstein J Org Chem 2021, 17, 2570-2584.
New Electrophiles and Strategies for Mechanism-Based and Targeted Covalent Inhibitor Design
Sneha Ray and Andrew S. Murkin*
Biochemistry 2019, 58, 5234-5244.
The Nitro Group as a Masked Electrophile in Covalent Enzyme Inhibition
Sneha Ray, Dale F. Kreitler, Andrew M. Gulick, and Andrew S. Murkin*
ACS Chem Biol 2018, 13, 1470-1473.
Mechanism-based Inactivator of Isocitrate Lyases 1 and 2 from Mycobacterium Tuberculosis
Truc V. Pham, Andrew S. Murkin, Margaret M. Moynihan, Lawrence Harris, Peter C. Tyler, Nishant Shetty, James C. Sacchettini, Hsiao-ling Huang, and Thomas D. Meek*
Proc Nat Acad Sci 2017, 114, 7617-7622.
Ohm’s Law as an Analogy for Enzyme Kinetics
Andrew S. Murkin*
Biochem Mol Biol Educ 2015, 43, 139-141.
Svetlana A. Kholodar, C. Leigh Allen, Andrew M. Gulick, and Andrew S. Murkin, A.*
J Am Chem Soc 2015, 137, 2748-2756.
Mechanism and Inhibition of 1-Deoxy-D-xylulose-5-phosphate Reductoisomerase
Andrew S. Murkin,* Kathryn A. Manning, and Svetlana A. Kholodar
Bioorg Chem 2014, 57, 171-185.
Svetlana A. Kholodar, Gregory Tombline, Juan Liu, Zhesen Tan, C. Leigh Allen, Andrew M. Gulick, and Andrew S. Murkin*
Biochemistry 2014, 53, 3423-3431.
Transition-State-Guided Drug Design for Treatment of Parasitic Neglected Tropical Diseases
Andrew S. Murkin* and Margaret M. Moynihan
Curr Med Chem 2014, 21, 1781-1793.
Margaret M. Moynihan and Andrew S. Murkin*
Biochemistry 2014, 53, 178-187.
Svetlana A. Kholodar and Andrew S. Murkin*
Biochemistry 2013, 52, 2302-2308.
Kathryn A. Manning, Bharathwaj Sathyamoorthy, Alexey Eletsky, Thomas Szyperski, Andrew S. Murkin*
J Am Chem Soc 2012, 134, 20589-20592.
Juan Liu and Andrew S. Murkin*
Biochemistry 2012, 51, 5307-5319.
Peer-Reviewed Journal Articles Prior to UB
** joint first author
Cassera, M.B.; Hazleton, K.Z.; Merino, E.F.; Obaldia III, N.; Ho, M.-C.; Murkin, A.S.; DePinto, R.; Gutierrez, J.A.; Almo, S.C.; Evans, G.B.; Babu, Y.S.; Schramm, V.L. Plasmodium falciparum parasites are killed by a transition state analogue of purine nucleoside phosphorylase in a primate animal model. PLoS ONE 2011, 6, e26916.
Silva, R.G.; Murkin, A.S.; Schramm, V.L. Femtosecond dynamics coupled to chemical barrier crossing in a Born-Oppenheimer enzyme. Proc. Natl. Acad. Sci. USA 2011, 108, 18661-18665.
Silva, R.G.; Hirschi, J.S.; Ghanem, M.; Murkin, A.S.; Schramm, V.L. Arsenate and phosphate as nucleophiles at the transition states of human purine nucleoside phosphorylase. Biochemistry 2011, 50, 2701-2709.
Ghanem, M.**; Murkin, A.S.**; Schramm, V.L. Ribocation Transition State Capture and Rebound in Human Purine Nucleoside Phosphorylase. Chem. Biol. 2009, 16, 971-979.
Bettiol, E.; Samanovic, M.; Murkin, A.S.; Raper, J.; Buckner, F.; Rodriguez, A. Identification of Three Classes of Heteroaromatic Compounds with Activity Against Intracellular Trypanosoma cruzi by Chemical Library Screening. PLoS Negl. Trop. Dis. 2009, 3, e384.
Clinch, K.; Evans, G.B.; Furneaux, R.H.; Kelly, P.M.; Legentil, L.; Murkin, A.S.; Li, L.; Schramm, V.L.; Tyler, P.C.; Woolhouse, A.D. Third Generation Immucillins: Acyclic Immucillins as Inhibitors of Purine Nucleoside Phosphorylase J. Med. Chem. 2009, 52, 1126-1143.
Murkin, A.S.; Clinch, K.; Mason, J.M.; Tyler, P.C.; Schramm, V.L. Immucillins in Custom Catalytic-Site Cavities Bioorg. Med. Chem. Lett. 2008, 18, 5900-5903 (Special issue invitation).
Mason, J.M.; Murkin, A.S.; Li, L.; Schramm, V.L.; Gainsford, G.J.; Skelton, B.W. A b‑Fluoroamine Inhibitor of Purine Nucleoside Phosphorylase J. Med. Chem. 2008, 51, 5880-5884.
Evans, G.B.; Furneaux, R.H.; Greatrex, B.; Murkin, A.S.; Schramm, V.L.; Tyler, P.C. Azetidine Based Transition State Analogue Inhibitors of N-Ribosyl Hydrolases and Phosphorylases J. Med. Chem. 2008, 51, 948-956.
Murkin, A.S.; Tyler, P.C.; Schramm, V.L. Transition State Interactions Revealed in Purine Nucleoside Phosphorylase by Binding Isotope Effects J. Am. Chem. Soc. 2008, 130, 2166-2167.
Rinaldo-Matthis, A.; Murkin, A.S.; Ramagopal, U.; Clinch, K.; Mee, S.P.H.; Evans, G.B.; Tyler, P.C.; Furneaux, R.H.; Almo, S.C.; Schramm, V.L. L-Enantiomers of Transition State Analogue Inhibitors Bound to Human Purine Nucleoside Phosphorylase J. Am. Chem. Soc. 2008, 130, 842-844.
Murkin, A.S.; Birck, M.R.; Rinaldo-Matthis, A.; Shi, W.; Taylor, E.A.; Almo, S.C.; Schramm, V.L. Neighboring Group Participation in the Transition State of Human Purine Nucleoside Phosphorylase Biochemistry 2007, 46, 5038-5049.
Deng, H.; Murkin, A.S.; Schramm, V.L. Phosphate Activation in the Ground State of Purine Nucleoside Phosphorylase J. Am. Chem. Soc. 2006, 128, 7765-7771.
Taylor Ringia, E.A.; Tyler, P.C.; Evans, G.B.; Furneaux, R.H.; Murkin, A.S.; Schramm, V.L. Transition State Analogue Discrimination by Related Purine Nucleoside Phosphorylases J. Am. Chem. Soc. 2006, 128, 7126-7127.
Murkin, A.S.; Chou, W.K.; Wakarchuk, W.W.; Tanner, M.E. Identification and Mechanism of a Bacterial Hydrolyzing UDP-N-Acetylglucosamine 2-Epimerase Biochemistry 2004, 43, 14290-14298.
Vann, W.F.; Daines, D.A.; Murkin, A.S.; Tanner, M.E.; Chaffin, D.O.; Rubens, C.E.; Vionnet, J.; Guerry, P.; Silver, R.P. The NeuC Protein of Escherichia coli K1 Is a Uridine Diphosphate N-Acetylglucosamine 2-Epimerase J. Bacteriol. 2004, 186, 706-712.
Murkin, A.S.; Tanner M. E. Dehydroalanine-Based Inhibition of a Peptide Epimerase from Spider Venom J. Org. Chem. 2002, 67, 8389-8394.